Benzoyl peroxide is an antibacterial ingredient, and it’s very effective at killing the P. acnes bacteria that causes breakouts. But benzoyl isn’t without its downsides. The leave-on creams and cleansing treatments can dry out sensitive skin and bleach clothing if you aren’t careful. Board-certified dermatologist Eric Meinhardt, M.D., previously told SELF that it's best to stick to formulations that have no more than 2 percent of benzoyl peroxide listed on the active ingredients chart; stronger concentrations are harder on your skin without being any tougher on bacteria.
There’s evidence that eating a low glycemic diet, meaning one that doesn’t include lots of processed grains/flour products and added sugar, is one the best home remedies for acne because it can help prevent it.  Glycemic index measures how quickly foods raise blood sugar. Processed and refined foods, like those common in the Western diet, are high-glycemic, while meats and whole plant foods are low on the glycemic scale.
For the treatment of face acne, orange peel can be an effective home remedy. Put some orange peels in the sun to dry out. Grind these dried peels into powder. Add water in the powder to make a paste. Apply the paste gently on the acne. Leave it for fifteen minutes and wash it off with warm water. Vitamin C present in orange helps in treating the acne on the face. It also helps in getting rid of pigmentation, blackheads, wrinkles, and dark spots.

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Sometimes birth control alone isn’t enough to really make a difference in hormonal acne. That’s when your doctor might recommend adding in an androgen blocker such as spironalactone. Spiro (as it’s often called) minimizes the amount of androgen hormones in circulation by blocking the receptors that bind with testosterone. When these pills are taken at the same time as an oral contraceptive, many women see an improvement in breakouts, according to Dr. Linkner. The drug is sometimes prescribed to women with PCOS (polycystic ovarian syndrome) to relieve androgen-related symptoms like excessive hair growth, hypertension, oily skin, and acne.

Salicylic acid and azelaic acid. Azelaic acid is a naturally occurring acid found in whole-grain cereals and animal products. It has antibacterial properties. A 20 percent azelaic acid cream seems to be as effective as many conventional acne treatments when used twice a day for at least four weeks. It's even more effective when used in combination with erythromycin. Prescription azelaic acid (Azelex, Finacea) is an option during pregnancy and while breast-feeding. Side effects include skin discoloration and minor skin irritation.
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